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[The relationship between resting heart rate and target organs damage in senile essential hypertension]

Ping Liu1, Su-jia Wang, Yun Zhang

  • 1Department of Cardiovascular Disease, Qilu Hospital, Shandong University, Jinan 250012, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|June 1, 2005
PubMed

Insights

Resting heart rate (RHR) is linked to target organ damage in elderly hypertension. Higher RHR correlates with increased carotid artery thickness and reduced kidney function, indicating RHR as a significant risk factor.

Area of Science:

  • Cardiology
  • Gerontology
  • Hypertension Research

Background:

  • Senile essential hypertension is a prevalent condition in the elderly population.
  • Target organ damage (TOD) is a major complication of uncontrolled hypertension.
  • The role of resting heart rate (RHR) in TOD among elderly hypertensive patients requires further investigation.

Purpose of the Study:

  • To explore the association between resting heart rate (RHR) and target organ damage (TOD) in elderly patients with essential hypertension.
  • To determine if RHR is an independent risk factor for TOD in this demographic.

Main Methods:

  • A cohort of 206 elderly essential hypertensive patients (60-85 years) was stratified by systolic blood pressure (SBP) and RHR levels.
  • Investigated organ damage using electrocardiography, carotid ultrasonography, echocardiography, creatinine clearance rate (CCr), and 24-hour urinary microalbuminuria (MAU).

Main Results:

  • Higher RHR (RHR5 group, ≥80 bpm) was associated with lower microalbuminuria (MAU) and left ventricular ejection fraction (LVEF).
  • Elevated RHR (RHR4 and RHR5 groups) correlated with increased carotid intima-medial thickness (IMT), carotid arterial diameter (CAD), and reduced CCr and MAU.
  • RHR showed positive correlations with IMT, CAD, left ventricular mass index (LVMI), and MAU, and negative correlations with LVEF and CCr (all P < 0.01).

Conclusions:

  • Resting heart rate (RHR) is significantly associated with target organ damage in senile essential hypertension.
  • RHR emerges as a crucial risk factor contributing to organ damage in elderly hypertensive patients.
  • Clinical management of senile hypertension should consider RHR alongside blood pressure parameters.
Abstract

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