Related Experiment Video
Updated: Feb 5, 2026
08:03
In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
8.5K
[China coronary secondary prevention study (CCSPS)].
1Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Zhonghua Xin Xue Guan Bing Za Zhi
|June 1, 2005
Summary
Xuezhikang significantly reduced cardiac events and mortality in Chinese patients with coronary heart disease (CHD). This lipid-lowering therapy proved effective and safe, lowering risks of myocardial infarction, CHD death, and overall mortality.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Clinical Trials
Context:
- Chinese population with coronary heart disease (CHD) exhibits lower mean serum cholesterol than Western populations.
- Assessing the efficacy of lipid-lowering therapy in this demographic is crucial.
Purpose:
- To evaluate if Xuezhikang, a lipid-lowering therapy, can reduce cardiac events and total mortality in Chinese CHD patients.
- To assess the safety and efficacy of Xuezhikang compared to placebo.
Summary:
- A randomized, double-blind, placebo-controlled trial involving 4870 Chinese CHD patients was conducted over eight years.
- Xuezhikang treatment significantly reduced primary endpoints (nonfatal myocardial infarction and CHD death) by 45.1% (P=0.0000).
- Secondary endpoints, including stroke, tumor, and PCI/CABG, also decreased by 31.1% (P<0.0004), with no significant side effects.
Impact:
- Xuezhikang significantly decreases the incidence of nonfatal myocardial infarction and deaths from CHD.
- The therapy also reduces the need for PCI/CABG, total mortality, and tumor-related deaths.
- Results demonstrate Xuezhikang's potential as an effective treatment for managing CHD in Chinese patients.
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