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[China coronary secondary prevention study (CCSPS)]

Zong-Liang Lu1,

  • 1Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|June 1, 2005
PubMed

Insights

Xuezhikang significantly reduced cardiac events and mortality in Chinese patients with coronary heart disease (CHD). This lipid-lowering therapy proved effective and safe, lowering risks of myocardial infarction, CHD death, and overall mortality.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Trials

Context:

  • Chinese population with coronary heart disease (CHD) exhibits lower mean serum cholesterol than Western populations.
  • Assessing the efficacy of lipid-lowering therapy in this demographic is crucial.

Purpose:

  • To evaluate if Xuezhikang, a lipid-lowering therapy, can reduce cardiac events and total mortality in Chinese CHD patients.
  • To assess the safety and efficacy of Xuezhikang compared to placebo.

Summary:

  • A randomized, double-blind, placebo-controlled trial involving 4870 Chinese CHD patients was conducted over eight years.
  • Xuezhikang treatment significantly reduced primary endpoints (nonfatal myocardial infarction and CHD death) by 45.1% (P=0.0000).
  • Secondary endpoints, including stroke, tumor, and PCI/CABG, also decreased by 31.1% (P<0.0004), with no significant side effects.

Impact:

  • Xuezhikang significantly decreases the incidence of nonfatal myocardial infarction and deaths from CHD.
  • The therapy also reduces the need for PCI/CABG, total mortality, and tumor-related deaths.
  • Results demonstrate Xuezhikang's potential as an effective treatment for managing CHD in Chinese patients.
Abstract

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