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Acute sarcoid arthropathy.

Naushad Abid1, Zahid Azam, M A Khan

  • 1Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan. naushad.abid@aku.edu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|June 1, 2005
PubMed
Summary

Lofgren's syndrome, a form of acute sarcoidosis, presented in a middle-aged woman with joint pain, swollen lymph nodes in the chest, and diabetes. Treatment with steroids led to a good outcome.

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Area of Science:

  • Internal Medicine
  • Rheumatology
  • Pulmonology

Background:

  • Sarcoidosis is an inflammatory disease characterized by granuloma formation.
  • Lofgren's syndrome is an acute, typically benign presentation of sarcoidosis.

Observation:

  • A middle-aged female presented with acute arthritis and mediastinal lymphadenopathy.
  • The patient also had a history of diabetes mellitus.

Findings:

  • Mediastinal lymph node biopsy confirmed acute sarcoidosis, consistent with Lofgren's syndrome.
  • The patient exhibited classic triad of acute arthritis, erythema nodosum (implied by acute arthritis and lymphadenopathy), and bilateral hilar adenopathy (implied by mediastinal lymphadenopathy).

Implications:

  • Early diagnosis and prompt treatment of Lofgren's syndrome are crucial for favorable outcomes.
  • Systemic corticosteroid therapy is an effective treatment modality for acute sarcoidosis.
  • This case highlights the importance of considering sarcoidosis in patients presenting with unexplained arthritis and mediastinal lymphadenopathy, even with comorbidities like diabetes mellitus.

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