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Xanthones from Garcinia cowa Roxb. latex.
W Mahabusarakam1, P Chairerk, W C Taylor
1Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. wilawan.m@psu.ac.th
Phytochemistry
|June 1, 2005
Summary
Garcinia cowa Roxb. latex yielded five new xanthones, cowagarcinone A-E, and six known ones. These compounds and the latex were tested for radical scavenging activity, showing potential antioxidant properties.
Area of Science:
- Natural Products Chemistry
- Phytochemistry
- Medicinal Chemistry
Background:
- Garcinia cowa Roxb. is a plant species known for its potential medicinal properties.
- Xanthones are a class of organic compounds with diverse biological activities.
- Latex from medicinal plants is a rich source of bioactive compounds.
Purpose of the Study:
- To isolate and characterize novel xanthone derivatives from Garcinia cowa Roxb. latex.
- To evaluate the radical scavenging potential of isolated compounds and crude latex.
- To explore the antioxidant capacity of Garcinia cowa Roxb. constituents.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through comprehensive spectroscopic analysis (NMR, MS).
- In vitro assessment of radical scavenging activity using established assays.
Main Results:
- Five new xanthones, named cowagarcinone A-E, were successfully isolated and identified.
- Six known xanthones were also isolated from the same source.
- The crude latex and purified xanthones exhibited varying degrees of radical scavenging activity.
Conclusions:
- The study successfully identified new xanthone structures from Garcinia cowa Roxb.
- The findings suggest that Garcinia cowa Roxb. latex possesses significant antioxidant potential.
- Further research into these xanthones may lead to the development of new antioxidant agents.