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Intranasally administered Cholecystokinin decreases controlled memory.
Ronald Schneider1, Carmen Stöhr, Reinhard Pietrowsky
1Heinrich-Heine-University Düsseldorf, Institute of Experimental Psychology, Department of Clinical Psychology, Geb. 23.03.U1, Universitätsstr. 1, 40225 Düsseldorf, Germany. schneiro@uni-duesseldorf.de
Biological Psychology
|June 1, 2005
Summary
Cholecystokinin (CCK) impacts human memory. This study found intranasal CCK impaired controlled recollection but not automatic familiarity, suggesting a specific effect on memory processes.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Pharmacology
Background:
- The neuropeptide Cholecystokinin (CCK) is known to modulate memory processes.
- Understanding CCK's specific role in human memory requires differentiating between controlled and automatic memory components.
Purpose of the Study:
- To investigate the effect of intranasally administered CCK on controlled recollection and automatic familiarity in humans.
- To determine if CCK differentially affects distinct memory processes.
Main Methods:
- Utilized a modified Jacoby's process dissociation procedure to separate controlled recollection from automatic familiarity.
- Administered intranasal CCK or a placebo to participants immediately after learning phases.
- Assessed recognition memory 30 minutes post-learning.
Main Results:
- Intranasal CCK significantly decreased controlled recollection compared to the placebo.
- Automatic familiarity was not significantly affected by CCK administration.
- Behavioral, physiological, and subjective control variables remained unaffected by CCK.
Conclusions:
- CCK has a differential effect on human memory processes, specifically impairing controlled recollection.
- The findings suggest CCK may interfere with the consolidation and/or retrieval of verbal material.
- Further research is warranted to elucidate the precise mechanisms of CCK's influence on memory.