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Radiation therapy for orbital lymphoma.

Ping Zhou1, Andrea K Ng, Barbara Silver

  • 1Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. pzhou@partners.org

International Journal of Radiation Oncology, Biology, Physics
|June 1, 2005
PubMed
Summary

Radiotherapy effectively treats orbital lymphoma, with a 30 Gy dose sufficient for indolent types. This approach shows high local control and low distant relapse rates for localized orbital lymphoma.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Ophthalmology

Background:

  • Orbital lymphoma is a rare malignancy affecting the eye socket.
  • Understanding optimal radiation techniques and outcomes is crucial for patient management.

Purpose of the Study:

  • To detail radiation therapy methods used for orbital lymphoma.
  • To assess the efficacy and toxicity of radiotherapy in treating orbital lymphoma.

Main Methods:

  • Retrospective analysis of 46 patients (62 eyes) treated with radiotherapy between 1987-2003.
  • Characterization of lymphoma subtypes (e.g., mucosa-associated lymphoid tissue, follicular).
  • Evaluation of radiation doses, techniques (electrons/photons), and follow-up duration (median 46 months).

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Main Results:

  • High local control rates (98% overall, 100% for indolent lymphoma).
  • Excellent 5-year freedom-from-distant-relapse (89%) and disease-specific survival (95%) for localized disease.
  • Cataract formation was the primary late toxicity, particularly without lens shielding.

Conclusions:

  • A radiation dose of 30 Gy appears adequate for indolent orbital lymphomas.
  • Orbital radiotherapy demonstrates favorable outcomes, with lower distant relapse rates than other lymphoma sites.
  • Radiotherapy is a viable salvage option for recurrent indolent orbital lymphoma.