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Coeliac disease in children

Alessio Fasano1, Carlo Catassi

  • 1School of Medicine, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland, 22 S. Pine St HSFII Building, Room 345, Baltimore, MD 21201, USA. afasano@mbrc.umaryland.edu

Best Practice & Research. Clinical Gastroenterology
|June 1, 2005
PubMed

Insights

Coeliac disease (CD) presents with a wide spectrum of symptoms in children, from typical malabsorption to silent or latent cases. Early diagnosis through serological testing is crucial for pediatricians to prevent long-term complications.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Immunology

Background:

  • Coeliac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
  • While often diagnosed in childhood, CD presents a broad clinical spectrum.
  • Associated complications like reduced bone density and neurological issues can occur in children.

Purpose of the Study:

  • To highlight the diverse clinical presentations of coeliac disease in children.
  • To emphasize the importance of early diagnosis and awareness among pediatric healthcare providers.
  • To underscore the need for timely intervention to prevent severe outcomes of untreated CD.

Main Methods:

  • Review of the clinical spectrum of coeliac disease in pediatric populations.
  • Analysis of associated comorbidities and long-term complications.
  • Discussion on the role of serological screening in early detection.

Main Results:

  • Coeliac disease in children manifests as typical, atypical, silent, or potential/latent cases.
  • Extra-intestinal symptoms and associated conditions are prevalent in pediatric CD.
  • Timely diagnosis through serological tests is vital for managing CD.

Conclusions:

  • Pediatricians and subspecialists require high awareness of CD's varied presentations.
  • Liberal use of serological tests aids in early identification of pediatric coeliac disease.
  • Prompt diagnosis and management are essential to mitigate serious complications.

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