Weight loss with meal replacement and meal replacement plus snacks: a randomized trial

Area of Science:

• Nutrition Science
• Weight Management Research
• Clinical Trials

Background:

• Structured meal replacement (MR) programs are utilized for weight loss.
• The role of snacking within these programs requires further investigation.
• Understanding dietary patterns can optimize weight management strategies.

Purpose of the Study:

• To determine if incorporating snacks influences weight loss and maintenance outcomes.
• To compare the effectiveness of a standard MR program versus an MR program augmented with snacks (MRPS).
• To assess the impact of snacking preference on treatment response in an MR program.

Main Methods:

• A 24-week prospective randomized trial involving 100 overweight participants.
• Participants were randomized into two groups: standard MR (no snacks) or MRPS (three snacks daily).
• Caloric intake was restricted to 1200 kcal/day for women and 1500 kcal/day for men.

Main Results:

• All participants achieved significant weight loss, averaging 4.6 kg by week 24, irrespective of snacking group.
• No significant difference in weight loss or maintenance was observed between the MR and MRPS groups.
• Significant improvements in systolic blood pressure, cholesterol, LDL, glucose, and insulin levels were noted across all groups.

Conclusions:

• Participant preference for snacking did not alter their response to the meal replacement weight loss program.
• Both snackers and non-snackers demonstrated comparable outcomes with either the standard MR or the MRPS approach.
• Snacking habits do not appear to be a critical factor in the efficacy of this structured meal replacement intervention.