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Topiramate in migraine prophylaxis.

D D'Amico¹, L Grazzi, S Usai

¹U.O. Cefalee e Malattie Cerebrovascolari, C. Besta National Neurological Institute, Via Celoria 11, I-20133, Milan, Italy. damicodo@tiscali.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|June 1, 2005

Summary

Topiramate (TPM) is an effective and well-tolerated medication for migraine prevention. Clinical trials confirm its efficacy, with a high response rate and no significant side effects like weight gain.

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Area of Science:

Neurology
Pharmacology

Background:

Migraine is a common neurological disorder.
Effective prophylactic treatments are needed.

Purpose of the Study:

To review placebo-controlled trial results for topiramate (TPM) in migraine prophylaxis.
To discuss clinical practice considerations for TPM.

Main Methods:

Review of double-blind, placebo-controlled trials.
Analysis of a comparative trial.

Main Results:

Topiramate (TPM) demonstrated efficacy in migraine prevention.
High responder rates and good tolerability at 100 mg/day.
Lack of major contraindications and weight gain observed.

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Conclusions:

Topiramate (TPM) is an effective and well-accepted option for migraine prophylaxis.
Slow titration and target dose of 100 mg/day are recommended.
TPM offers a favorable profile for long-term migraine management.