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Evaluation of left ventricular function in long-term survivors of childhood Hodgkin disease

Diana Iarussi1, Carlo Pisacane, Paolo Indolfi

  • 1Cattedra di Cardiologia, Dipartimento di Scienze Cardio-Chirurgiche, Toraciche e Respiratorie, Seconda Università di Napoli. dianal.iarussi@unina2.it

Pediatric Blood & Cancer
|June 1, 2005
PubMed

Insights

Long-term Hodgkin disease survivors often have subtle cardiac abnormalities. The myocardial performance index (MPI) effectively detects these issues in most patients.

Area of Science:

  • Cardiology
  • Oncology
  • Pediatric Oncology

Background:

  • Conflicting data exists regarding myocardial abnormalities in Hodgkin disease (HD) survivors.
  • Doxorubicin chemotherapy is a known cardiotoxic agent used in HD treatment.
  • Early detection of cardiac dysfunction is crucial for long-term survivor health.

Purpose of the Study:

  • To evaluate the utility of the myocardial performance index (MPI) in detecting cardiac abnormalities.
  • To assess cardiac function in long-term survivors of Hodgkin disease treated with doxorubicin.

Main Methods:

  • Echocardiographic evaluation was conducted on 31 Hodgkin disease survivors (mean age 17.0 years).
  • Survivors received doxorubicin chemotherapy (median dose 164.8 +/- 42.5 mg/m²).
  • A control group of 22 healthy subjects (mean age 16.7 years) was included for comparison.

Main Results:

  • Hodgkin disease survivors showed significantly increased Peak A velocity and decreased peak E/A velocity ratio.
  • Patients exhibited prolonged isovolumetric contraction time and shorter ejection time compared to controls.
  • The myocardial performance index (MPI) was significantly higher in survivors (83% abnormal MPI), indicating impaired cardiac function.

Conclusions:

  • The Doppler-derived myocardial performance index (MPI) is a sensitive tool for detecting subtle cardiac abnormalities.
  • The majority of Hodgkin disease survivors treated with doxorubicin exhibit cardiac dysfunction.
  • MPI can aid in the early identification and management of cardiotoxicity in cancer survivors.
Abstract

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