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10'-Desmethoxystreptonigrin, a novel analog of streptonigrin
W C Liu1, M Barbacid, M Bulgar
1Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
The Journal of Antibiotics
|April 1, 1992
Abstract:
10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of RAS p21 protein. The compound was isolated from the fermentation broth and its structure determined. It is markedly cytotoxic to several human tumor cell lines and also exhibits potent broad-spectrum antibacterial activity.