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Design optimization of blood shearing instrument by computational fluid dynamics
Jingchun Wu1, James F Antaki, Trevor A Snyder
1LaunchPoint Technologies, LLC, Goleta, CA 93117, USA. jwu@launchpnt.com
Artificial Organs
|June 2, 2005
Summary
This study developed a Blood Shearing Instrument (BSI) to precisely control shear stress on blood. The optimized design minimizes flow issues, improving shear homogeneity for better blood-wetted device research.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Materials Science
Background:
- Designing blood-wetted devices requires understanding shear-induced trauma.
- Accurate in vitro shear exposure is difficult with conventional methods.
- Homogeneous shear history is crucial for device testing.
Purpose of the Study:
- Develop a Blood Shearing Instrument (BSI) for controlled shear stress.
- Optimize the flow path for homogeneous shear exposure.
- Investigate shear stress up to 1500 Pa and exposure times from 0.0015-0.20 s.
Main Methods:
- Utilized computational fluid dynamics (CFD) for flow path optimization.
- Employed a parameterized geometric model and automatic mesh generation.
- Analyzed flow and shear fields within the BSI's rotating and stationary components.
Main Results:
- Initial designs showed unfavorable pressure gradients, vortices, and reverse flow.
- Optimized design eliminated vortices and reverse flow, improving homogeneity.
- Shape optimization enhanced homogeneity, though limitations in annular devices remain.
Conclusions:
- The developed BSI offers improved control over shear stress exposure.
- CFD-driven optimization significantly enhanced flow path performance.
- Further refinement is needed to overcome inherent limitations of annular shear devices.