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Published on: December 8, 2023
[Subureteral polydimethylsiloxane injection for the endoscopic treatment of vesicoureteral reflux]
C Soto Beauregard1, F Rivilla Parra, J García Casillas
1Servicio de Cirugía Pediátrica, Hospital Universitario San Carlos, 28040 Madrid, España. msoto.hcsc@salud.madrid.org
Insights
Endoscopic subureteral polydimethylsiloxane injection effectively treats pediatric vesicoureteral reflux (VUR) with low morbidity. This minimally invasive procedure offers a safe and well-tolerated option for managing VUR in children.
Area of Science:
- Pediatric Urology
- Minimally Invasive Surgery
- Biomaterials in Medicine
Context:
- Vesicoureteral reflux (VUR) is a common condition in children, increasing the risk of urinary tract infections and kidney damage.
- Traditional open surgery for VUR can be invasive, carrying risks of significant morbidity.
- Endoscopic subureteral injection offers a less invasive alternative for VUR treatment.
Purpose:
- To evaluate the effectiveness, long-term follow-up, and morbidity of subureteral polydimethylsiloxane injection for treating pediatric VUR.
- To assess the success rates of single and multiple polydimethylsiloxane injections.
- To identify factors influencing treatment outcomes.
Summary:
- A study of 28 children with VUR treated with endoscopic subureteral polydimethylsiloxane injection showed an 86% success rate after one or two injections.
- Mean follow-up was 18 months, with low morbidity reported.
- Factors such as reflux grade and implant characteristics influenced effectiveness.
Impact:
- Subureteral polydimethylsiloxane injection is a simple, well-tolerated procedure with low morbidity for pediatric VUR.
- This technique can be successfully applied to complex cases, including bilateral VUR.
- The findings support endoscopic subureteral injection as a viable treatment option, potentially reducing the need for open surgery.
Introduction:
Endoscopic subureteral injection has been successfully used to treat vesicoureteral reflux (VUR) in children. The aim of this study was to review our results with subureteral polydimethylsiloxane injection in terms of effectiveness, long term follow-up and morbidity.
Material And Method:
Twenty-eight children with VUR were treated with this technique. VUR was unilateral in eight patients (28.6%) and bilateral in 20 patients (71.4%). Indications for endoscopic treatment were the same as those for open surgery. The polydimethylsiloxane implant was injected transureterally below the ureteral meatus in 50 ureters on an outpatient basis. Reflux grade was low (II-III) in 36% and high (IV-V) in 64%.
Results:
The mean follow-up was 18 months (12 months-4 years). VUR was corrected in 43 ureters (86%) corresponding to 21 patients. Reflux resolved in 40 ureters after one polydimethylsiloxane injection (80%) and in 43 ureters (86%) after two injections. An endoscopic retreatment to correct the reflux was performed in six ureteral units. Cystoscopic findings in these patients with endoscopic failure were mound displacement toward the bladder neck in five ureters and marked volume loss on the mound in one. All these patients underwent a second subureteral dose, which controlled VUR in three ureters (50%).
Conclusions:
Our results confirm that endoscopic subureteral polydimethylsiloxane treatment is a simple procedure with low morbidity that is well tolerated by the patient. In our experience, it can be used in double ureters. The effectiveness of this procedure seems to be related to the grade of reflux, the cystoscopic appearance of the ureteral orifice, volume loss and mound displacement.
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