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Related Experiment Videos

Lung tissue resistance during contractile stimulation: structural damping decomposition.

M S Ludwig1, F M Robatto, S Simard

  • 1Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 1, 1992
PubMed
Summary

Structural damping offers a new view of lung tissue mechanics. Dissipative losses in lung tissue are linked to elastic stress, not just viscous stress, simplifying how we understand tissue resistance (Rti).

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Area of Science:

  • Pulmonary Mechanics
  • Soft Tissue Rheology
  • Respiratory Physiology

Background:

  • Traditional research links lung tissue dissipation to viscous stress, defining tissue viscous resistance (Rti).
  • The structural damping hypothesis proposes dissipation is more dependent on elastic stress than viscous stress.
  • This suggests a fundamental coupling between dissipative and elastic processes in lung tissues.

Purpose of the Study:

  • To investigate the role of structural damping in lung tissue mechanics.
  • To differentiate contributions to tissue viscous resistance (Rti) using the structural damping paradigm.
  • To analyze how airway constriction and volume history affect Rti components.

Main Methods:

  • Induced alterations in canine Rti using aerosols of prostaglandin F2 alpha, histamine, and methacholine.

Related Experiment Videos

  • Manipulated lung volume history in canine subjects.
  • Applied the structural damping paradigm to separate Rti changes into elastance (Edyn) and dissipation coupling (eta) components.

    • Main Results:

    • Changes in dynamic elastance (Edyn) explained most Rti changes from contractile stimulation and volume history.
    • The coefficient of coupling of dissipation to elastance (eta) changed with constriction but minimally impacted Rti from volume history.
    • Structural damping analysis revealed Edyn response strongly correlates with Rti response.

    Conclusions:

    • Structural damping provides a simplified phenomenological model for lung tissue mechanics.
    • Changes in eta during constriction may reflect alterations in cross-bridge kinetics or cellular stress-bearing.
    • When dynamic elastance changes, tissue viscous resistance is compelled to respond similarly.