Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mismatch negativity in schizophrenia: a meta-analysis.

Daniel Umbricht1, Sanya Krljes

  • 1University of Zurich, Department of Psychiatric Research, Psychiatric University Hospital Zurich, Switzerland. umbricht@bli.unizh.ch

Schizophrenia Research
|June 2, 2005
PubMed
Summary

Mismatch negativity (MMN) deficits are common in schizophrenia, indicating impaired auditory processing. While duration of illness correlated with frequency MMN deficits, other factors showed no significant association.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linking human brain functional connectivity to underlying neurotransmission.

bioRxiv : the preprint server for biology·2026
Same author

A Phase 2b Multicenter Study to Evaluate Basmisanil as an Adjunctive Treatment in Patients With Cognitive Impairment Associated With Schizophrenia.

The Journal of clinical psychiatry·2026
Same author

A novel psychedelic 5-HT<sub>2A</sub> receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer.

Journal of psychopharmacology (Oxford, England)·2025
Same author

Relapse in Schizophrenia: A Systematic Review of Criteria for Clinical Studies and International Consensus Guidelines to Improve Them.

The American journal of psychiatry·2025
Same author

Using the grip strength effort task to measure reward processing dysfunction in schizophrenia and major depressive disorder.

Neuroscience applied·2025
Same author

Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial.

BMC medicine·2025

Area of Science:

  • Neuroscience
  • Psychiatry
  • Auditory Processing

Background:

  • Mismatch negativity (MMN) is an auditory event-related potential reflecting automatic auditory processing and sensory memory.
  • Abnormal MMN generation is frequently reported in schizophrenia.
  • This study aimed to quantify the MMN deficit in schizophrenia and identify associated factors.

Purpose of the Study:

  • To conduct a meta-analysis of MMN studies in schizophrenia.
  • To estimate the overall effect size of MMN deficits.
  • To investigate factors influencing MMN abnormalities.

Main Methods:

  • A meta-analysis was performed on 32 studies of MMN in schizophrenia.
  • Effect sizes were calculated and analyzed.
  • Factors examined included illness duration, patient demographics, MMN type, and paradigm characteristics.

Related Experiment Videos

Main Results:

  • The mean effect size for MMN deficits in schizophrenia was 0.99.
  • No single factor significantly correlated with MMN deficits overall.
  • Duration of illness showed a significant correlation with frequency MMN deficits.

Conclusions:

  • MMN deficits are a consistent finding in chronic schizophrenia, highlighting auditory processing and memory impairments.
  • MMN may serve as an indicator of neuropathological changes in the auditory cortex.
  • Findings suggest MMN abnormalities may evolve with illness duration.