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Related Experiment Videos

Basigin (EMMPRIN/CD147) interacts with integrin to affect cellular architecture.

Kathryn D Curtin1, Ian A Meinertzhagen, Robert J Wyman

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA. kcurtin@uark.edu

Journal of Cell Science
|June 2, 2005
PubMed
Summary

Basigin, an IgG glycoprotein, plays a crucial role in cell architecture and cytoskeletal organization, independent of its known matrix remodeling functions. This study reveals novel intracellular functions of basigin in cell structure maintenance.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • Basigin, an IgG family glycoprotein, is known to stimulate matrix metalloproteinase secretion in human metastatic tumors.
  • Its role in remodeling the extracellular matrix is well-established.
  • However, intracellular functions of basigin remained largely unexplored.

Purpose of the Study:

  • To investigate novel, matrix metalloproteinase-independent roles of basigin.
  • To elucidate the function of basigin in intracellular architecture and cell structure maintenance.
  • To explore the interaction between basigin and integrin in cellular organization.

Main Methods:

  • Utilized Drosophila melanogaster as a model organism.
  • Investigated basigin's function in cultured insect cells and photoreceptor cells.

Related Experiment Videos

  • Examined the colocalization and genetic interaction of basigin and integrin.

    • Main Results:

    • Basigin interacts with integrin and is essential for normal cell architecture in certain cell types.
    • Basigin promotes cytoskeletal rearrangements and lamellipodia formation in cultured insect cells.
    • Loss of basigin in photoreceptors caused defects in nuclear, ER, and mitochondrial positioning, and axon terminal swelling, indicating cytoskeletal disruption.

    Conclusions:

    • Basigin has intracellular roles in maintaining cell architecture and cytoskeletal organization, independent of extracellular matrix remodeling.
    • The interaction between basigin and integrin is critical for basigin-mediated cellular architecture.
    • Basigin and integrin may form complexes to organize internal cell structure.