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Acute coffee ingestion does not affect LDL cholesterol level.

Rebecca J Cheung1, Eric K Gupta, Matthew K Ito

  • 1Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA, USA.

The Annals of Pharmacotherapy
|June 2, 2005
PubMed
Summary
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Drinking coffee before a blood test may slightly alter lipid levels. Black coffee increased total cholesterol and HDL-C, while coffee with additives decreased triglycerides, though changes were not clinically significant.

Area of Science:

  • Clinical Chemistry
  • Nutritional Science
  • Cardiovascular Health

Background:

  • Fasting blood tests for lipid analysis are standard, but coffee consumption before these tests is common.
  • The impact of pre-test coffee intake on fasting serum lipid profiles remains unclear.

Purpose of the Study:

  • To investigate the effect of a single 6-oz cup of coffee on fasting plasma lipid profiles.
  • To assess if coffee with or without nondairy creamer and sugar significantly alters lipid measurements.

Main Methods:

  • A prospective, randomized crossover study involving 40 participants.
  • Participants consumed either black coffee or coffee with additives, followed by blood draws for lipid analysis.
  • The procedure was repeated with participants crossing over to the alternate coffee preparation.

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Main Results:

  • Black coffee consumption led to statistically significant increases in total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C).
  • Coffee with nondairy creamer and sugar resulted in a statistically significant decrease in triglycerides.
  • No significant changes were observed in low-density lipoprotein cholesterol (LDL-C).

Conclusions:

  • A single cup of coffee consumed shortly before blood draw causes statistically significant, but not clinically significant, changes in lipid levels.
  • These findings suggest that while coffee may affect lipid measurements, the clinical relevance is minimal.