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Teaching resources. Nuclear receptors.

Reshma Taneja1

  • 1Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. reshma.taneja@mssm.edu

Science'S STKE : Signal Transduction Knowledge Environment
|June 2, 2005
PubMed
Summary

This resource covers nuclear receptors, detailing their structure, transcriptional regulation, and phosphorylation modulation. It explores the critical role of nuclear receptors in cancer development and progression.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Nuclear receptors are crucial transcription factors involved in various cellular processes.
  • Understanding nuclear receptor function is vital for comprehending cell signaling pathways.

Purpose of the Study:

  • To provide lecture materials on nuclear receptors for graduate students.
  • To elucidate the structure, function, and regulation of nuclear receptors.
  • To highlight the involvement of nuclear receptors in oncogenesis.

Main Methods:

  • Lecture notes and slides format.
  • Discussion of nuclear receptor structure.
  • Explanation of transcriptional regulation mechanisms.
  • Analysis of phosphorylation-mediated modulation.
  • Review of nuclear receptors' role in cancer.

Main Results:

  • Comprehensive overview of nuclear receptor structure and function.
  • Detailed mechanisms of transcriptional regulation by nuclear receptors.
  • Insights into how phosphorylation affects nuclear receptor activity.
  • Exploration of the link between nuclear receptors and cancer.

Conclusions:

  • Nuclear receptors are key regulators of gene expression with implications in cancer.
  • This resource serves as a valuable teaching tool for graduate-level cell signaling courses.

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