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Related Experiment Videos

Falling backward in two elderly patients taking bupropion.

M P Szuba1, A F Leuchter

  • 1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine.

The Journal of Clinical Psychiatry
|May 1, 1992
PubMed
Summary
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Two geriatric patients experienced a unique backward falling side effect from bupropion (an antidepressant). This may be linked to its dopamine effects, suggesting caution in elderly populations.

Area of Science:

  • Neuroscience
  • Geriatric Medicine
  • Pharmacology

Background:

  • Bupropion is a novel antidepressant with fewer reported adverse effects than tricyclic antidepressants.
  • It exhibits weak norepinephrine and serotonin reuptake inhibition but significant dopamine agonist and reuptake blocking effects.

Observation:

  • Two geriatric patients treated with bupropion for major depression experienced an unusual side effect.
  • This side effect involved unexpectedly falling backward during treatment.

Findings:

  • The backward falls were not explained by orthostatic hypotension or vertigo.
  • Patients exhibited symptoms consistent with parkinsonian syndrome, suggesting a link to dopaminergic pathways.

Implications:

Related Experiment Videos

  • This bupropion-induced side effect may be unique among antidepressants and mediated by dopaminergic effects in the basal ganglia.
  • Clinicians should monitor geriatric patients for parkinsonian symptoms and backward falls when prescribing bupropion.