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Updated: Jul 30, 2026
07:05
Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Botulinum toxin injections for paediatric incontinence
Brigitte Schurch1, Jacques Corcos
1Neuro-Urology, Swiss Paraplegic Centre, Balgrist University Hospital, 8008 Zurich, Switzerland. bschurch@paralab.balgrist.ch
Current Opinion in Urology
|June 2, 2005
Summary
Botulinum A toxin injections offer a minimally invasive alternative for treating overactive bladders in children when other methods fail. This approach shows promise as a safe and effective option compared to traditional surgery.
Area of Science:
- Pediatric Urology
- Neurology
- Pharmacology
Background:
- Neurogenic detrusor overactivity (NDO) in children often requires treatment beyond standard anticholinergics.
- Intractable NDO historically necessitated invasive surgical interventions like bladder augmentation.
- Botulinum A toxin presents a novel, less invasive therapeutic option.
Purpose of the Study:
- To review the emerging role of botulinum A toxin injections as an alternative treatment for pediatric NDO.
- To evaluate the efficacy and safety profile of botulinum A toxin in pediatric patients with refractory overactive bladder.
- To compare botulinum A toxin therapy with existing surgical and pharmacological treatments.
Main Methods:
- Review of existing literature on botulinum A toxin use in pediatric NDO.
- Analysis of reported clinical benefits and safety data from published studies.
- Extrapolation of data from adult studies and understanding of the toxin's mechanism of action on the detrusor muscle.
Main Results:
- Limited but growing evidence suggests clinical benefit and a favorable safety profile for botulinum A toxin in NDO.
- No reported instances of drug resistance or detrimental ultrastructural changes in the detrusor following repeated injections.
- Data from adult populations support the potential efficacy in pediatric cases.
Conclusions:
- Botulinum A toxin is a viable alternative to surgery for managing intractable pediatric overactive bladders.
- Further research is needed to optimize delivery methods, injection sites, and dosage for long-term outcomes.
- Minimally invasive botulinum A toxin injections show promise for improving quality of life in children with NDO.
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