[The arthritic pathologies accompanying primary immunodeficiencies with antibody synthesis disturbances]

The problem of arthritis in patients with primary antibody defects is presented in this study. We describe the most common kinds of arthritis (septic, viral, and aseptic), their etiology and treatment. Other diseases characterized by a lack of immunoglobulin are also shown. The most common diseases in primary hypogammaglobulinemia, especially autoimmune disorders, are dealt with. Many disease-modifying drugs (gold, D-penicillamine, sulfasalazine, azathioprine) cause symptomatic hypogammaglobulinemia in some patients. We emphasize the role of intravenous immunoglobulin replacement therapy in the reduction of the arthritis. The possibility of immunodeficiency should be kept in mind when evaluating patients with arthritis.