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Related Experiment Videos

Urinary phytoestrogen concentrations in the U.S. population (1999-2000).

Liza Valentín-Blasini1, Melissa A Sadowski, Donna Walden

  • 1National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. LValentin@cdc.gov

Journal of Exposure Analysis and Environmental Epidemiology
|June 2, 2005
PubMed
Summary

Phytoestrogen levels in US adults and adolescents vary by age and race. Enterolactone and daidzein were most common, with differences observed across demographic groups.

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Area of Science:

  • Environmental Health
  • Nutritional Science
  • Biomarkers

Background:

  • Phytoestrogens are plant-derived compounds with potential health benefits.
  • Understanding population exposure is crucial for assessing health impacts.

Purpose of the Study:

  • To report population-based urinary concentrations of key phytoestrogens.
  • To stratify these concentrations by age, sex, and race/ethnicity.

Main Methods:

  • Analysis of approximately 2500 urine samples from the National Health and Nutrition Examination Survey (NHANES) 1999-2000.
  • Measurement of isoflavones (genistein, daidzein, equol, O-DMA) and lignans (enterolactone, enterodiol).
  • Multivariate statistical analyses to identify demographic differences.

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Main Results:

  • Phytoestrogens were detected in over 70% of samples; enterolactone and daidzein were most prevalent.
  • Geometric means ranged from 3.95 (O-DMA) to 217 (enterolactone) microg/g creatinine.
  • Significant demographic variations were observed, with adolescents and non-Hispanic whites showing distinct patterns.

Conclusions:

  • Urinary phytoestrogen levels in the US population exhibit significant demographic variability.
  • These findings provide a baseline for understanding phytoestrogen exposure.
  • Further research can elucidate the role of phytoestrogens in disease prevention.