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Fusion of Secretory Vesicles with the Plasma Membrane01:26

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Related Experiment Video

Updated: May 25, 2026

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
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Annexins: linking Ca2+ signalling to membrane dynamics.

Volker Gerke1, Carl E Creutz, Stephen E Moss

  • 1Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Münster, Germany. gerke@uni-muenster.de

Nature Reviews. Molecular Cell Biology
|June 2, 2005
PubMed
Summary
This summary is machine-generated.

Annexins are calcium-dependent proteins linking cell signaling to membrane functions. They organize membrane domains and recruit proteins, influencing cell dynamics, differentiation, and migration.

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Last Updated: May 25, 2026

Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
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Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators

Published on: March 22, 2019

Area of Science:

  • Molecular and Cellular Biology
  • Biochemistry
  • Cell Signaling

Background:

  • Eukaryotic cells utilize calcium ions (Ca2+) as crucial second messengers.
  • Various Ca2+-effector proteins translate intracellular Ca2+ signals into cellular responses.
  • Annexins represent a unique protein family interacting with phospholipids in a Ca2+-dependent manner.

Purpose of the Study:

  • To elucidate the role of annexins in linking Ca2+ signaling to membrane functions.
  • To explore annexins' capabilities in organizing membrane domains and protein recruitment.
  • To understand annexins' involvement in diverse cellular processes such as membrane dynamics, differentiation, and migration.

Main Methods:

  • Investigated Ca2+-dependent binding of annexins to membrane phospholipids.
  • Analyzed annexin-mediated network formation on membrane surfaces.
  • Examined annexin interactions with other proteins and their functional consequences.

Main Results:

  • Annexins bind to specific membrane phospholipids in response to Ca2+.
  • Annexins form organized networks on membrane surfaces, acting as scaffolds.
  • These networks facilitate the recruitment of interacting proteins, influencing cellular events.

Conclusions:

  • Annexins serve as a critical link between Ca2+ signaling and membrane-associated processes.
  • Their ability to organize membrane domains and recruit proteins underlies their diverse cellular functions.
  • Annexins are key players in fundamental cellular events including membrane dynamics, differentiation, and migration.