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Updated: Jun 19, 2026

In vivo and in vitro Studies of Adaptor-clathrin Interaction
Published on: January 27, 2011
CLIPs and CLASPs and cellular dynamics
1Department of Cell Biology and Genetics, Erasmus Medical Centre, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands. n.galjart@erasmusmc.nl
Abstract:
The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.
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