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Review of some molecular and physiological studies of histamine H1 receptor function (Hiroshi Wada Symposium)

H Fukui1

  • 1Department of Molecular Pharmacology, Institute of Health Biosciences, Graduate School, The University of Tokushima, Tokushima 770-8505, Japan. hfukui@ph.tokushima-u.ac.jp

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|June 2, 2005
PubMed
Abstract

No abstract available in PubMed .

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The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...