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Variant lymphoproliferative disorder of granular lymphocytes (LDGL) following Hodgkin lymphoma

Brian Douglas Jenkins1, Daniel Snower, Anwar Mohamed

  • 1The Van Elslander Cancer Center, St. John Hospital and Medical Center, Detroit, Michigan 48236, USA.

American Journal of Hematology
|June 2, 2005
PubMed

Insights

A rare CD3(+) CD4(+) CD8(+) variant of lymphoproliferative disorder of granular lymphocytes (LDGL) was incidentally discovered in a patient in remission from Hodgkin lymphoma (HL). This case presents documented clonal chromosomal abnormalities, a novel finding in this context.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Hodgkin lymphoma (HL) is a malignancy of lymphocytes.
  • Lymphoproliferative disorder of granular lymphocytes (LDGL) is a rare condition characterized by an overgrowth of granular lymphocytes.
  • Treatment for HL can sometimes lead to secondary conditions.

Observation:

  • A patient in remission from stage III-B HL was incidentally diagnosed with a CD3(+) CD4(+) CD8(+) variant of LDGL.
  • The patient was asymptomatic and showed no signs of HL recurrence or immune disorder.
  • Lymphocytosis was detected during routine follow-up after HL therapy.

Findings:

  • The diagnosis of variant LDGL was confirmed through laboratory analysis.
  • Clonal chromosomal abnormalities, specifically 46, XX, t(2;6;2;11) (p13;q23;q24;q23), were identified in 20% of peripheral blood lymphocytes.
  • Fluorescence in situ hybridization (FISH) analysis confirmed the breakpoint on 11q23 was distal to the MLL gene.

Implications:

  • This is the first reported case of a variant LDGL associated with HL treatment.
  • The presence of documented clonal chromosomal abnormalities in this context is a significant new finding.
  • Further research may explore the relationship between HL treatment, chromosomal changes, and the development of LDGL.

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