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High resolution CT findings in miliary lung disease
G McGuinness1, D P Naidich, J Jagirdar
1Department of Radiology, New York University Medical Center-Bellevue Hospital, NY.
Journal of Computer Assisted Tomography
|May 1, 1992
Summary
High-resolution CT (HRCT) effectively identifies infectious miliary lung disease, often seen in human immunodeficiency virus (HIV) patients. HRCT reveals characteristic nodules and septal thickening, aiding diagnosis.
Area of Science:
- Radiology
- Pulmonology
- Infectious Diseases
Background:
- Miliary lung disease presents diagnostic challenges, particularly in immunocompromised individuals.
- Distinguishing infectious etiologies requires sensitive imaging modalities.
Purpose of the Study:
- To compare high-resolution CT (HRCT) and chest radiographs in diagnosing miliary lung disease.
- To characterize HRCT findings associated with infectious miliary lung disease, especially in HIV-positive patients.
Main Methods:
- Comparative analysis of HRCT and chest radiographs in nine patients with miliary lung disease.
- Pathologic correlation was used to interpret CT findings.
- Clinical data, including human immunodeficiency virus (HIV) status, were considered.
Main Results:
- HRCT demonstrated a consistent pattern of 1-3 mm nodules (sharply and poorly defined), nodular septal thickening, and vascular irregularities in all patients.
- Many poorly defined nodules mimicked airspace disease.
- Diffuse septal thickening was observed in 91% of cases.
Conclusions:
- The HRCT findings, including nodular opacities and septal thickening, are characteristic of infectious miliary lung disease.
- HRCT shows promise for early diagnosis, particularly in human immunodeficiency virus (HIV)-positive patients.
- Prospective studies are needed to confirm the role of HRCT in early miliary disease diagnosis in HIV patients.