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[ATC and EphMRA classifications: evolution from 1996 to 2003 and comparative analysis].

Corinne Tollier1, Isabelle Fusier, Marie-Caroline Husson

  • 1Centre National Hospitalier d'Information sur le Medicament, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. ctollier@wanadoo.fr

Therapie
|June 3, 2005
PubMed
Summary

Comparing drug classification systems, the Anatomical Therapeutic Chemical (ATC) and European Pharmaceutical Marketing Research Association (EphMRA) evolve independently. While integrated into the Thériaque database, they retain distinct structures and specific uses in pharmacotherapy.

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Area of Science:

  • Pharmacology
  • Drug Information Systems
  • Health Informatics

Background:

  • Health practitioners utilize diverse pharmacotherapeutic classifications, hindering drug information exchange.
  • International and European classifications improve drug information diffusion.
  • The French "Hospital National Center of Drugs Information" (CNHIM) integrated ATC and EphMRA classifications into its "Thériaque" database.

Purpose of the Study:

  • To analyze the evolution of ATC and EphMRA classification systems between 1996 and 2003.
  • To compare the code allocations of ATC and EphMRA for drugs within the Thériaque database in January 2002.

Main Methods:

  • Comparative analysis of ATC and EphMRA classification systems using data-processing requests.
  • Examination of classification structure, hierarchy levels, and allocation of codes to drugs.

Related Experiment Videos

  • Tracking annual changes including additions, suppressions, modifications, and subdivisions within both systems.

    • Main Results:

    • Both ATC (5 levels) and EphMRA (3-4 levels) classifications exhibit annual evolution.
    • ATC links to active substances and drugs; EphMRA links to drugs within Thériaque.
    • Key differences in Thériaque allocations include EphMRA class K ("Hospital solutions") vs. ATC class B ("Blood and blood forming organ"), and EphMRA class T ("Diagnostic agents") vs. ATC class V ("Various").

    Conclusions:

    • Pharmacotherapeutic classification systems like ATC and EphMRA evolve in parallel or independently.
    • Despite close relationships, ATC and EphMRA maintain specific structures and uses.
    • The integration into Thériaque highlights the distinct yet complementary nature of these drug classification systems.