Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kidney aging: from phenotype to genetics.

Michele Buemi1, Lorena Nostro, Carmela Aloisi

  • 1Department of Internal Medicine, University of Messina, Messina, Italy. buemim@unime.it

Rejuvenation Research
|June 3, 2005
PubMed
Summary

Physiological aging causes kidney structure and function changes in elderly individuals. Further research into molecular mechanisms like oxidative stress and telomere length is needed to understand and treat kidney aging.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cuff Shaving in Recurrent Exit-Site Infections in a Patient on Peritoneal Dialysis].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2024
Same author

[Peritoneal Dialysis Network in North-East Italy: Survey About the Peritoneal Catheter Exit-Site Infection Management and Comparison with ISPD Guidelines].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2024
Same author

[Omentopexy in Peritoneal Catheter Malfunction].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2023
Same author

Indole-3-acetic acid correlates with monocyte-to-high-density lipoprotein (HDL) ratio (MHR) in chronic kidney disease patients.

International urology and nephrology·2022
Same author

Renal involvement in sarcoidosis: histological patterns and prognosis, an Italian survey.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2021
Same author

[A case of AL amyloidosis with fulminant evolution].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia·2020

Area of Science:

  • Gerontology
  • Nephrology
  • Molecular Biology

Background:

  • Aging is a natural physiological process leading to structural and functional decline in body systems, including the kidneys.
  • Kidney function in the elderly can be affected by genetic factors, environmental agents, and comorbidities like atherosclerosis and hypertension.
  • The inevitability and rate of renal function decline solely due to physiological aging remain unclear.

Purpose of the Study:

  • To explore the molecular mechanisms underlying kidney tissue damage during aging.
  • To investigate the impact of aging on renal function and identify potential intervention points.
  • To enhance the clinical management and therapeutic options for kidney aging and transplantation.

Main Methods:

  • Review of current literature on physiological aging and kidney function.

Related Experiment Videos

  • Analysis of molecular pathways implicated in age-related kidney damage.
  • Exploration of the roles of nitric oxide, oxidative stress, renin-angiotensin system, telomere length, and klotho gene expression.

    • Main Results:

    • Aging involves structural and functional changes in the kidneys, potentially leading to organ failure.
    • Comorbidities significantly impact the kidney's ability to adapt to age-related structural changes.
    • Specific molecular mechanisms require further in-depth investigation.

    Conclusions:

    • Understanding the molecular basis of kidney aging is crucial for developing targeted interventions.
    • Improved knowledge of physiological renal aging can refine clinical approaches and expand transplantation possibilities.
    • Further research into key molecular players is essential for addressing age-related kidney decline.