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[Bone quality in osteogenesis imperfecta]
1Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmacology.
Abstract:
Osteogenesis imperfecta is heritable disease that is characterized by bone fragility and low bone mass. The disorder is mainly caused by mutations in either the procollagen type I alpha1 or the procollagen type I alpha2. In general, the mutation in either gene may cause less amount of type I collagen molecule or less integrated type I collagen molecule, low quality. The former is much less severe than the latter. Bisphosphonate treatment improves bone fragility in the disease by the inhibition of increased bone turnover. This may indicates that the beneficial effects of the treatment may due to improvement of the decreased bone mass.
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