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Calcinosis universalis: a rare diagnosis.
Cláudio Santili1, Miguel Akkari, Gilberto Waisberg
1Orthopaedics and Traumatology Department, Santa Casa São Paulo, Faculty of Medical Sciences, São Paulo, Brazil. dotped@santacasasp.org.br
Journal of Pediatric Orthopedics. Part B
|June 3, 2005
Summary
Calcinosis universalis involves calcium salt deposits in soft tissues, often appearing in childhood. This review details a case study, highlighting diagnostic challenges and treatment considerations for this rare condition.
Area of Science:
- Rheumatology
- Dermatology
- Pediatrics
Background:
- Calcinosis universalis is a rare condition characterized by widespread calcium salt deposition in skin, subcutaneous tissues, tendons, and muscles.
- Onset typically occurs within the first decade of life, presenting with diverse clinical manifestations ranging from joint pain to restricted movement.
Observation:
- The case study details the 28-month evolution of calcinosis universalis.
- Laboratory and radiographic findings were systematically documented throughout the observation period.
Findings:
- The study emphasizes the importance of differential diagnosis, distinguishing calcinosis universalis from conditions like fibrodysplasia ossificans progressive and myositis ossificans.
- Review of literature and case presentation provide insights into the diagnostic process for soft tissue calcification.
Implications:
- Current treatment options for calcinosis universalis are limited and often focus on symptom management.
- The paper discusses potential therapeutic strategies including calcium chelates (EDTA), bisphosphonates, and steroids.
- Further research is needed to establish effective treatments for calcinosis universalis.