Related Experiment Video
Updated: Aug 17, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
Iron status in 6-y-old children: associations with growth and earlier iron status
B S Gunnarsson1, I Thorsdottir, G Palsson
1Unit for Nutrition Research, Landspitali - University Hospital and Department of Food Science, University of Iceland, Reykjavik, Iceland. bsg@hi.is
Insights
Children with lower iron stores at younger ages experienced slower growth. Faster early childhood growth was linked to poorer iron status by age six, suggesting a complex relationship between nutrition and development.
Area of Science:
- Pediatric Nutrition
- Child Growth and Development
- Hematology
Background:
- Iron deficiency is a global health concern affecting child development.
- Understanding the interplay between iron status and growth is crucial for early intervention.
- Longitudinal data on iron status and growth in early childhood are essential.
Purpose of the Study:
- To assess the iron status of 6-year-old children.
- To examine the association between iron status and growth parameters.
- To investigate the relationship between earlier iron status and current iron status and growth.
Main Methods:
- A cross-sectional study involving 139 children (74% participation rate) from previous cohorts.
- Collection of body size measurements and blood samples near the child's sixth birthday.
- Analysis of iron status indicators including serum ferritin (SF) and mean corpuscular volume (MCV).
Main Results:
- No iron deficiency anemia was observed; however, 16% of children had depleted iron stores (SF < 15 microg/l).
- Iron status indices at 6 years were generally higher than at 1 and 2 years, with correlations noted.
- Hemoglobin concentration at 6 years was negatively associated with length gain from birth to 1 year; faster weight gain was observed in children with depleted iron stores.
Conclusions:
- Low iron status in early childhood (1-2 years) may be associated with slower growth up to age 6.
- Slower growth or low iron status in early years could contribute to poorer iron status at age 6.
- Conversely, faster growth in early childhood appears related to lower iron status at age 6.
Objective:
To investigate the iron status of 6-y-old children and its association with growth and earlier iron status.
Design:
In a cross-sectional study, children's body size measurements were recorded and blood samples taken near their sixth birthday.
Subjects:
A sample of 188 children, randomly selected in two previous studies, was contacted, and 139(74%) agreed to participate.
Results:
No children had iron deficiency anaemia, one was iron-deficient (serum ferritin (SF) <15 microg/l and mean corpuscular volume (MCV) <76 fl but 16% had depleted iron stores (SF<15 microg/l). Iron status indices were generally higher than at 1 and 2 y, but correlation was seen between iron status indices at 6 y and earlier values. Haemoglobin concentration at 6 y was negatively associated with length gain from birth to 1 y (B+/-s.e.=-1.269+/-0.452; P=0.007; adj. R2=0.119) (n=52), and proportional weight gain from birth to 1 y was higher among children with SF<15 microg/l at 6 y (295+/-33%; n=10) than those with SF> or =15 microg/l (258+/-31%; n=49) (P=0.001). MCV at 2 y predicted weight gain from 2 to 6 y (B+/-s.e.=1.721+/-0.581; P=0.005; adj. R2=0.153) (n=44); also, children with SF<15 microg/l at 6 y (n=9) gained 7.8+/-1.2 kg from 2 to 6 y, while children with SF> or =15 microg/l (n=35) gained 9.6+/-2.8 kg (P=0.007), furthermore a difference was seen in proportional weight gain from 2 to 6 y between children with depleted iron stores at 2 y and not, or 156+/-13 vs 169+/-18% (P=0.038).
Conclusion:
The results suggest that low iron status at 1 and 2 y might lead to slower growth up to 6 y of age. Low iron status at 1 and 2 y and/or slower growth from 1 and 2 y up to 6 y might contribute to worse iron status at 6 y, while faster growth in early childhood is related to lower iron status.
Related Concept Videos
Environmental Influences on Intelligence
Nature and Nurture
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Microbes and Other Elemental Cycles
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...

