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Protein kinases in drug discovery and development

Y R Hadari1

  • 1ImClone Systems Inc, 180 Varick Street 6th Floor, New York, NY 10014, USA. yaronh@imclone.com

Idrugs : the Investigational Drugs Journal
|June 3, 2005
PubMed

Insights

Protein kinases are validated targets for treating diseases like cancer. Inhibiting specific kinases shows efficacy and acceptable toxicity, offering potential for multi-disease therapeutic agents.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Protein kinases are crucial targets in drug discovery, particularly for cancer therapy.
  • Over 600 kinases encoded by the human genome are subjects of extensive academic and industrial research.
  • Mutations or overexpression of specific kinases are implicated in various diseases.

Purpose of the Study:

  • To highlight protein kinases as validated therapeutic targets.
  • To discuss the strategy of using genomic and clinical data for novel target identification.
  • To outline the drug discovery process centered around target kinases.

Main Methods:

  • Review of preclinical and clinical evaluations of protein kinase inhibitors.
  • Identification of novel targets using genomic information and clinical research.
  • Establishment of drug discovery projects around chosen target kinases.

Main Results:

  • Protein kinase inhibitors demonstrate significant efficacy and acceptable toxicity.
  • A single kinase can be a target for multiple diseases.
  • Genomic-driven strategies are central to modern drug discovery.

Conclusions:

  • Protein kinases represent validated therapeutic targets with broad applicability.
  • Targeting specific kinases offers potential for treating diverse diseases.
  • Integrated genomic and clinical approaches drive the identification and development of novel kinase-targeted drugs.

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