Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fuel oxidation during human walking.

Wayne T Willis1, Kathleen J Ganley, Richard M Herman

  • 1Department of Kinesiology, Arizona State University, Tempe, AZ 85287-0404, USA. waynewillis@asu.edu

Metabolism: Clinical and Experimental
|June 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does hemoglobin affect measures of mitochondrial respiration in red blood cells? Comment to "Increased retention of functional mitochondria in mature sickle red blood cells is associated with increased sickling tendency, hemolysis and oxidative stress".

Haematologica·2024
Same author

Nonequilibrium thermodynamics and mitochondrial protein content predict insulin sensitivity and fuel selection during exercise in human skeletal muscle.

Frontiers in physiology·2023
Same author

Can non-equilibrium thermodynamics explain skeletal muscle insulin resistance due to low mitochondrial content?

The lancet. Diabetes & endocrinology·2023
Same author

Fuel Selection in Skeletal Muscle Exercising at Low Intensity; Reliance on Carbohydrate in Very Sedentary Individuals.

Metabolic syndrome and related disorders·2022
Same author

Site-specific acetylation of adenine nucleotide translocase 1 at lysine 23 in human muscle.

Analytical biochemistry·2021
Same author

Deletion of Von Willebrand A Domain Containing Protein (VWA8) raises activity of mitochondrial electron transport chain complexes in hepatocytes.

Biochemistry and biophysics reports·2021

Human adults prefer a characteristic walking speed. This study found that preferred walking speed minimizes carbohydrate use, suggesting the brain may select this speed to reduce effort and reliance on carbohydrates.

Area of Science:

  • Human locomotion
  • Exercise physiology
  • Metabolic control

Background:

  • The mechanisms underlying preferred walking speed (PWS) in humans are not fully understood.
  • Understanding PWS is crucial for comprehending human movement and energy expenditure.

Purpose of the Study:

  • To investigate the relationship between walking speed, fuel utilization, and the perception of effort.
  • To determine if metabolic factors influence the central nervous system's control of locomotion.

Main Methods:

  • Indirect calorimetry was used to measure fuel oxidation (carbohydrate and fat) during treadmill walking at various speeds.
  • Participants walked at speeds ranging from 3.2 to 7.2 km/h.
  • Perception of effort (RPE) and other physiological variables were recorded.

Related Experiment Videos

Main Results:

  • Oxygen cost of transport was lowest near PWS but not significantly different at slightly higher speeds.
  • Carbohydrate oxidation rates were low at speeds below PWS and increased abruptly above 4.8 km/h.
  • Carbohydrate oxidation explained 70% of the variance in RPE, with speed contributing an additional 4%.

Conclusions:

  • PWS is maintained below a threshold where carbohydrate oxidation significantly increases.
  • The central nervous system may regulate PWS to minimize reliance on carbohydrate metabolism and reduce perceived effort.
  • Skeletal muscle metabolic control is a key factor in the central motor control of human walking.