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[Relationship between peripheral insulin resistance and beta-cell function in obese subjects]
Hong-liang Li1, Ye-rong Yu, Hong-ling Yu
1Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
Summary
Obese individuals with normal blood glucose exhibit insulin resistance and impaired beta-cell function. Elevated free fatty acids (FFAs) may contribute to type 2 diabetes by worsening insulin resistance and beta-cell dysfunction.
Area of Science:
- Metabolic Syndrome
- Endocrinology
- Diabetes Pathogenesis
Context:
- Obesity is a growing global health concern linked to metabolic dysfunction.
- Understanding early markers of type 2 diabetes in obese individuals is crucial for prevention.
- Insulin resistance and beta-cell function are key determinants of glucose homeostasis.
Purpose:
- To investigate the relationship between peripheral insulin resistance and beta-cell function in obese subjects with normal blood glucose.
- To explore the role of free fatty acids (FFAs) in the development of type 2 diabetes mellitus (DM).
Summary:
- Obese subjects showed elevated baseline insulin, pro-insulin, and insulin resistance.
- Despite enhanced acute insulin response, obese individuals had impaired glucose disposal rates and higher post-glucose plasma levels.
- Elevated serum free fatty acids (FFAs) correlated negatively with glucose disposal rate in obese subjects.
Impact:
- Obesity is associated with significant peripheral insulin resistance and impaired beta-cell function, even with normal blood glucose levels.
- High circulating free fatty acids (FFAs) appear to be a contributing factor to both insulin resistance and beta-cell dysfunction.
- These findings suggest that elevated FFAs play a role in the pathogenesis of type 2 diabetes.