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Updated: Aug 17, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Predictors of headache 22 years after hospitalization for head injury
K Nestvold1, T Lundar, P Mowinckel
1Norwegian Health Services Research Centre, Lørenskog, Norway. knut.nestvold@ahus.no
Objectives:
To assess predictors of headache in patients who had sustained a head injury 22 years earlier.
Materials And Methods:
A questionnaire about headache was sent to 361 subjects hospitalized for head injury in 1974-1975.
Results:
A total of 249 patients (69%) responded to the questionnaire. The prevalence of headache >14 days a month last year was 11%. In multivariate logistic regression analysis female sex (OR = 3.4, 95% CI 1.2-9.6), severe headache 3 months after the head injury (OR = 10.6, 95% CI 2.6-43.5) and psychiatric disease (OR = 2.9, 95% CI 1.1-7.7) predicted chronic headache. There was no significant association between chronic headache and post-traumatic amnesia or other trauma-related variables.
Conclusion:
Female sex and headache 3 months after the head injury were the strongest predictors of long-term headache, while there was little association between long-term headache and trauma variables.
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