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Updated: Aug 17, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[Coronary intervention in 1148 patients with chronic total coronary occlusion]
Ya-ling Han1, Jian Zhang, Quan-min Jing
1Department of Cardiology, Shenyang General Hospital, Cardiovascular Research Institute of PLA, Shenyang 110016, China. hanyal@mail.sy.ln.cn
Insights
Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) lesions achieved high success rates (90.2%) and favorable outcomes in experienced centers. Factors like occlusion time and lesion length influenced success, with low major adverse cardiac events.
Area of Science:
- Interventional Cardiology
- Cardiovascular Research
- Vascular Medicine
Context:
- Chronic total occlusion (CTO) represents a significant challenge in percutaneous coronary intervention (PCI).
- Successful revascularization of CTO lesions can improve myocardial perfusion and patient outcomes.
- Limited data exists on the long-term outcomes and technical success rates of CTO PCI in large patient cohorts.
Purpose:
- To evaluate the technical success and clinical outcomes of PCI for patients with CTO lesions.
- To identify factors affecting PCI success in CTO lesions.
- To assess the safety and efficacy of CTO PCI procedures.
Summary:
- A retrospective analysis of 1148 patients with 1494 CTO lesions treated with PCI between 1993-2004.
- Overall success rates were 90.2% for patients and 88.2% for lesions.
- Success was lower for longer occlusions, stump issues, bridging collaterals, and lesions >= 15mm. In-hospital major adverse cardiac events were 0.6%.
Impact:
- Demonstrates that high success rates and favorable clinical outcomes are achievable with PCI for CTO lesions in experienced centers.
- Provides insights into factors influencing CTO PCI success, aiding procedural planning.
- Contributes to the understanding of the safety profile of CTO PCI, with low rates of major adverse cardiac events.
Objective:
To assess the technique and outcomes of coronary intervention treatment for patients with chronic total occlusion (CTO) lesions.
Methods:
Retrospectively analyzed the data from 1148 patients with CTO who were treated by percutaneous coronary intervention (PCI) between June 1993 and December 2004. There were 1494 CTO lesions in 1458 vessels with a mean occlusion time of (49.1 +/- 31.6) months. A total of 1499 stents were implanted to those target lesions.
Results:
Total success rates of patients and lesions were 90.2% (1036/1148) and 88.2% (1317/1494), respectively. The success rate of PCI was declined in CTO lesions with long occlusion time, stump missing, bridging collaterals and >or= 15 mm in length (P < 0.05). Operative failures were occurred in 112 patients. Guide wire and balloon failed to pass through the occlusion accounted for 82.1% and 17.9% of all failures respectively. No death was occurred during operation, but 2 patients suffered from acute stent thrombosis and other 9 patients suffered from acute or later pericardium perforation. After procedure, there were 3 patients died and 3 patients suffered from subacute stent thrombosis during in-hospital period. The total in-hospital major adverse cardiac events rate was 0.6% (7/1148). The angina-free survival rate was 87.1% at discharge.
Conclusion:
In an experienced heart center, it is possible to obtain a relatively high success rate of PCI and ideal clinical outcomes in patients with CTO coronary lesions.
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