Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene targeting with viral vectors.

Paul C Hendrie1, David W Russell

  • 1Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|June 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase 1 trial of venetoclax with cladribine, cytarabine, G-CSF, and mitoxantrone for AML and high-grade myeloid neoplasm.

Blood neoplasia·2025
Same author

Identification of factors predicting low-risk febrile neutropenia admissions in adults with acute myeloid leukemia.

Blood advances·2024
Same author

Hyper-CVAD versus dose-adjusted EPOCH as initial treatment for adults with acute lymphoblastic leukemia.

European journal of haematology·2023
Same author

Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML.

Blood advances·2023
Same author

Aleukemic mast cell leukemia, well-differentiated and chronic type.

Annals of hematology·2023
Same author

Phase II study of dose-adjusted EPOCH as initial therapy for adults with high-risk acute lymphoblastic leukemia.

Leukemia & lymphoma·2023

Gene targeting offers precise genetic modification advantages over gene addition. This review explores viral vectors, particularly adeno-associated virus vectors, for efficient gene targeting in research and therapy.

Area of Science:

  • Molecular Biology
  • Gene Therapy
  • Virology

Background:

  • Genetic manipulation is key for scientific and therapeutic advancements.
  • Gene targeting offers precise genomic alteration compared to gene addition.
  • Traditional gene targeting methods lack efficiency for applications like gene therapy.

Purpose of the Study:

  • To review the development of gene-targeting vectors.
  • To discuss viral vector systems, focusing on adeno-associated virus (AAV).
  • To explore the design, mechanisms, and applications of AAV-based gene-targeting vectors.

Main Methods:

  • Review of scientific literature on gene-targeting vectors.
  • Analysis of viral vector systems including retroviruses, adenoviruses, and adeno-associated viruses.

Related Experiment Videos

  • Focus on the design principles and functional aspects of AAV vectors for gene targeting.

    • Main Results:

    • Viral vectors have been developed for gene targeting.
    • Adeno-associated virus vectors show promise for enhanced gene targeting efficiency.
    • Specific design and mechanisms of AAV vectors are discussed.

    Conclusions:

    • Viral vectors, especially AAV, represent a significant advancement in gene-targeting technology.
    • AAV-based vectors offer potential for overcoming limitations of traditional methods in gene therapy.
    • Further research into AAV vector design and application is warranted.