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Therapeutic management of elderly hypertensives with concomitant ischaemic heart disease

G Licata1, R Scaglione, G Capuana

  • 1Department of Medical Pathology I, University of Palermo, Italy.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|April 1, 1992
PubMed

Insights

Managing hypertension in elderly patients with ischemic heart disease requires careful drug selection due to age-related physiological changes. This review examines effective therapeutic strategies for this complex patient group.

Area of Science:

  • Cardiology
  • Geriatrics
  • Pharmacology

Background:

  • Hypertension is highly prevalent in older adults, increasing with age.
  • Elderly patients with hypertension often have co-existing conditions like ischemic heart disease.
  • Age-related cardiovascular changes impact hemodynamics and neurohormone activity.

Purpose of the Study:

  • To review therapeutic management strategies for elderly hypertensives with ischemic heart disease.
  • To highlight the importance of considering age-related pharmacokinetic and pharmacodynamic changes.
  • To guide drug selection for efficacy in both conditions.

Main Methods:

  • Review of current literature on hypertension management in the elderly.
  • Analysis of drug classes including diuretics, beta-blockers, ACE inhibitors, and calcium channel blockers.
  • Consideration of drug interactions and side effects in older populations.

Main Results:

  • Age-related changes necessitate tailored drug selection for elderly hypertensives.
  • Specific drug classes show utility in managing concomitant hypertension and ischemic heart disease.
  • Elderly individuals are more susceptible to adverse drug reactions and interactions.

Conclusions:

  • Therapeutic choices must balance efficacy for hypertension and ischemic heart disease.
  • Pharmacokinetic and pharmacodynamic alterations in the elderly influence drug choice.
  • Careful selection of diuretics, beta-blockers, ACE inhibitors, and calcium channel blockers is recommended.
Abstract

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