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Colorectal carcinomatosis: a new oncologic frontier
1Washington Cancer Institute, Washington Hospital Center, DC 20010, USA. Paul.sugarbaker@medstar.net
Purpose Of Review:
In the past, carcinomatosis from colorectal cancer was determined to be a lethal condition with a short survival.
Recent Findings:
A new treatment strategy starts with cytoreductive surgery in an attempt to remove all visible evidence of cancer implants. Then, chemotherapy is used in the operating room with moderate hyperthermia (41-43 degrees C) in an attempt to eradicate microscopic residual disease. Multiple phase II, a phase III, and a multi-institutional phase II study of 503 patients showed that approximately one-third of these patients can survive long term.
Summary:
The expansion of treatment options, including cytoreductive surgery followed by chemotherapy with hyperthermia, to a larger number of patients is appropriate.
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