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Invasive Chromobacterium violaceum infection in children: case report and review
Sayomporn Sirinavin1, Chonnamet Techasaensiri, Suwat Benjaponpitak
1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
The Pediatric Infectious Disease Journal
|June 4, 2005
Insights
Chromobacterium violaceum infections can be severe, especially in children without chronic granulomatous disease (CGD). Prompt treatment is crucial for survival in invasive C. violaceum cases.
Area of Science:
- Pediatric Infectious Diseases
- Immunology
- Microbiology
Background:
- Invasive Chromobacterium violaceum infections are rare but can cause severe abscesses in multiple organs.
- Chronic granulomatous disease (CGD) is a primary immunodeficiency affecting neutrophil function.
- Understanding the clinical spectrum and outcomes of C. violaceum in children is essential for effective management.
Observation:
- A pediatric case of C. violaceum abscesses in the lungs, liver, and spleen in a child with CGD was successfully treated.
- A review of 25 invasive C. violaceum episodes in 24 children was conducted.
- Patient demographics, clinical presentation, and outcomes were analyzed.
Findings:
- All 9 children with CGD survived their C. violaceum infections.
- 10 non-bacteremic cases had a 100% survival rate.
- In contrast, 75% of non-CGD patients and 80% of bacteremic patients died, highlighting the critical role of immune status and bacterial dissemination.
Implications:
- CGD appears to be a significant protective factor against mortality in invasive C. violaceum infections.
- Early recognition and treatment of C. violaceum are vital, particularly in immunocompromised children.
- This study underscores the importance of diagnosing and managing underlying immunodeficiencies like CGD for improved patient outcomes.
Abstract:
A 3.3-year-old boy developed Chromobacterium violaceum abscesses of lungs, liver and spleen and was successfully treated. He had chronic granulomatous disease (CGD). Twenty-five episodes of invasive C. violaceum infection in 24 children were reviewed. All 9 CGD and 10 nonbacteremic cases survived, but 12 of 16 (75%) non-CGD and 12 of 15 (80%) bacteremic patients died.
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