Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Array-based comparative genomic hybridization in clinical diagnosis.

Bassem A Bejjani1, Aaron P Theisen, Blake C Ballif

  • 1Signature Genomic Laboratories, 44 West 6th Avenue, Suite 202, Spokane, WA 99204, USA. bejjani@signaturegenomics.com

Expert Review of Molecular Diagnostics
|June 7, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA methylation dysregulation patterns in the 1p36 region instability.

Journal of applied genetics·2024
Same author

COVID-19 and the adaptive evolution of genetic counseling.

Journal of genetic counseling·2022
Same author

Identification of a novel missense mutation in the fibroblast growth factor 5 gene associated with longhair in the Maine Coon Cat.

Human genetics·2021
Same author

Special issue on companion animal genetics: Novel variants discovered in wide variety of diseases in dogs, identification and further characterization of traits in dogs and cats, and the use of microarrays in the detection of aneuploidy in dogs.

Human genetics·2021
Same author

Radiographical Survey of Osteochondrodysplasia in Scottish Fold Cats caused by the TRPV4 gene variant.

Human genetics·2021
Same author

The PMEL gene and merle (dapple) in the dachshund: cryptic, hidden, and mosaic variants demonstrate the need for genetic testing prior to breeding.

Human genetics·2021
Same journal

Bacterial respiratory infections: advances in diagnostic strategies.

Expert review of molecular diagnostics·2026
Same journal

Artificial intelligence in molecular diagnostics for pandemic preparedness.

Expert review of molecular diagnostics·2026
Same journal

Navigating PD-L1 testing in immuno-oncology: analytical robustness, clinical validation, and the role of the VENTANA SP263 assay.

Expert review of molecular diagnostics·2026
Same journal

Extracellular vesicles as diagnostic and prognostic biomarkers in non-small cell lung cancer.

Expert review of molecular diagnostics·2026
Same journal

Explainable epigenetic aging clocks: an overview of existing AI models and approaches.

Expert review of molecular diagnostics·2026
Same journal

Neuro-axonal injury biomarker serum neurofilament light chain is associated with osteoarthritis: a dual-cohort study from NHANES and UK Biobank.

Expert review of molecular diagnostics·2026
See all related articles

High-throughput microarray technologies like array comparative genomic hybridization (array CGH) improve detection of genetic abnormalities in cancer and constitutional disorders. This advancement is revolutionizing medical genetics diagnostics and gene discovery.

Area of Science:

  • Genomics
  • Medical Genetics
  • Cancer Research

Background:

  • Human genome sequencing and high-throughput microarray technologies have advanced genetic analysis.
  • Microarray-based comparative genomic hybridization (array CGH) integrates molecular and traditional cytogenetics.

Purpose of the Study:

  • To highlight the impact of array CGH on medical genetics.
  • To explore the clinical applications of array CGH in defining genetic syndromes and cancer characterization.

Main Methods:

  • Utilizing high-throughput microarray technology.
  • Integrating molecular and traditional cytogenetics through array CGH.

Main Results:

  • Array CGH enhances the detection of copy number alterations.

Related Experiment Videos

  • Clinical applications include defining new genetic syndromes and expanding existing phenotypes.
  • Potential to characterize the genomic signature of cancers.

    • Conclusions:

    • Array CGH is becoming a primary diagnostic tool for chromosomal abnormalities.
    • The synergy of bioinformatics, robotics, and microarray technology heralds a new era in genetic analysis, diagnosis, and gene discovery.