Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prefrontal and striatal activation in elderly subjects during concurrent implicit and explicit sequence learning.

Howard J Aizenstein1, Meryl A Butters, Kristi A Clark

  • 1Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. aizen+@pitt.edu

Neurobiology of Aging
|June 7, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Attentional Control Profiles during Language Comprehension in Major Mental Health Disorders.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Exploring the Relationship Between Inflammatory Biomarkers and Negative Symptoms Subtypes in Individuals at Ultra-High Risk for Psychosis.

Early intervention in psychiatry·2026
Same author

Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm.

Bipolar disorders·2026
Same author

Impacted and preserved sub-domains of cognitive control in schizophrenia.

Neuropsychologia·2026
Same author

The Biological Psychiatry Family of Journals Is Rewarding Its Reviewers.

Biological psychiatry·2026
Same author

Prior Trial Effects on Working Memory in Schizophrenia, Bipolar Disorder, and Healthy Control Individuals.

JAMA psychiatry·2026
Same journal

Amygdala and hippocampal volumes as neural correlates of resilience and loneliness in older adults.

Neurobiology of aging·2026
Same journal

Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease.

Neurobiology of aging·2026
Same journal

Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span.

Neurobiology of aging·2026
Same journal

Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated.

Neurobiology of aging·2026
Same journal

How cognition and hearing-related measures covary with hippocampal subfield features from structural MRI in younger and older adults.

Neurobiology of aging·2026
Same journal

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.

Neurobiology of aging·2026
See all related articles

Cognitive aging involves changes in the prefrontal cortex (PFC) and neostriatum. Elderly individuals showed altered brain activation in these regions during sequence learning tasks, suggesting network-level changes related to aging.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Prefrontal cortex (PFC) dysfunction is a key aspect of cognitive aging.
  • The neostriatum's role in cognitive aging remains less understood despite its connection to the PFC.

Purpose of the Study:

  • To investigate the distinct cognitive roles of neostriatal and prefrontal function in elderly versus young individuals.
  • To examine brain activation patterns during implicit and explicit sequence learning in aging.

Main Methods:

  • Event-related functional MRI (fMRI) was employed.
  • Twenty healthy subjects (9 elderly, 11 young) performed a concurrent implicit and explicit sequence learning task.
  • Brain activity was measured during task performance.

Related Experiment Videos

Main Results:

  • Elderly subjects exhibited decreased activation in the left PFC for both implicit and explicit learning compared to young subjects.
  • Reduced activation in the right putamen during implicit learning was observed in the elderly.
  • Increased activation in the right PFC during explicit learning was noted in elderly individuals.

Conclusions:

  • Brain network changes, involving the dorsolateral prefrontal cortex and striatum, are associated with cognitive aging.
  • These age-related neural changes occur during implicit learning and may not require conscious awareness.