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From sensing cellular sterols to assembling sensory structures.

John P Incardona1

  • 1Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd E, Seattle, Washington 98112, USA.

Developmental Cell
|June 7, 2005
PubMed
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Novel genes in C. elegans extend a protein superfamily

Area of Science:

  • Genetics and developmental biology
  • Molecular and cellular biology

Background:

  • The C. elegans genome contains novel genes.
  • These genes belong to a superfamily with known roles in cholesterol homeostasis and Hedgehog signaling.
  • The superfamily includes Niemann-Pick C1, Patched, and Dispatched proteins.

Purpose of the Study:

  • To analyze Patched- and Dispatched-related proteins in C. elegans.
  • To extend the known functions of this protein superfamily.

Main Methods:

  • Genomic analysis of C. elegans.
  • Functional analysis of Patched- and Dispatched-related proteins.

Main Results:

  • Identification of novel genes within the superfamily in C. elegans.

Related Experiment Videos

  • Demonstration that these proteins are involved in tubular organ formation.
  • Expansion of the superfamily's known functions.

    • Conclusions:

    • The Patched- and Dispatched-related protein family in C. elegans plays a role in tubular organ development.
    • This finding broadens the functional repertoire of this important protein superfamily.