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Updated: Aug 17, 2026

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
Published on: September 2, 2016
Monitoring drug delivery processes by EPR and related techniques--principles and applications
1Department of Bio-Medical Physics and Bio-Engineering, Aberdeen University and Grampian University Hospitals, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. lurie@abdn.ac.uk
Abstract:
Electron Paramagnetic Resonance (EPR, or ESR) is a powerful non-invasive spectroscopic tool that can be used to monitor drug release processes in vitro and in vivo. Furthermore, spatial dissolution can be achieved by means of EPR-Imaging. The article introduces the basics of EPR and EPR-imaging. It discusses also the challenges of in vivo spectroscopy and imaging and presents information about new developments such as longitudinally detected EPR (LODEPR) and Proton Electron Double Resonance Imaging ((PEDRI). Examples of the usefulness of EPR in the field of drug delivery include the measurement of microviscosity and micropolarity, the direct detection of drug release mechanisms in vitro and in vivo, the monitoring of microacidity in biodegradable polymers and the characterisation of colloidal drug carriers.
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