Jove
Visualize
Contact Us

Related Experiment Videos

Associative learning: Hebbian flies.

David L Glanzman1

  • 1Department of Physiological Science and Neurobiology, UCLA, Los Angeles, California 90095-1761, USA. dglanzman@physci.ucla.edu

Current Biology : CB
|June 7, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Habituation and sensitization learning in adult solitary ascidians.

Scientific reports·2026
Same author

In Vivo Confocal Fluorescence Imaging of Neural Activity Induced by Sensory Stimulation in Partially Restrained Larval Zebrafish.

Journal of visualized experiments : JoVE·2025
Same author

The central importance of nuclear mechanisms in the storage of memory.

Biochemical and biophysical research communications·2021
Same author

Induction of Short-Term Sensitization by an Aversive Chemical Stimulus in Zebrafish Larvae.

eNeuro·2020
Same author

Isoform Specificity of PKMs during Long-Term Facilitation in <i>Aplysia</i> Is Mediated through Stabilization by KIBRA.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2019
Same author

Is plasticity of synapses the mechanism of long-term memory storage?

NPJ science of learning·2019
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Fruit flies learn through association. Disrupting N-methyl-D-aspartate (NMDA) receptors in flies impairs this olfactory conditioning, highlighting their crucial role in associative learning.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Molecular Biology

Background:

  • Fruit flies demonstrate associative learning, connecting odors with aversive stimuli like electric shock.
  • Olfactory conditioning is a key model for studying learning and memory mechanisms.

Purpose of the Study:

  • To investigate the role of N-methyl-D-aspartate (NMDA) receptors in olfactory associative learning in fruit flies.
  • To determine if disrupting NMDA receptor expression affects the flies' ability to learn odor-shock associations.

Main Methods:

  • Utilized genetic manipulation to disrupt the expression of NMDA receptors in specific neurons of Drosophila melanogaster.
  • Assessed olfactory conditioning by measuring the flies' learned avoidance of an odor previously paired with an electric shock.

Related Experiment Videos

Main Results:

  • Flies with disrupted NMDA receptor expression showed a significant impairment in olfactory conditioning.
  • The ability to associate an odor with an aversive stimulus was compromised when NMDA receptors were not properly expressed.

Conclusions:

  • NMDA receptors are critical for the neural processes underlying associative learning in fruit flies.
  • These findings support the involvement of NMDA receptor function in learning and memory consolidation across species.