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Updated: Aug 17, 2026
Embryo Microinjection and Electroporation in the Chordate Ciona intestinalis
Published on: October 16, 2016
Towards a molecular code for individuality in the absence of MHC: screening for individually variable genes in the
Konstantin Khalturin1, Ulrich Kürn, Nicole Pinnow
1Zoological Institute, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24098 Kiel Germany. kkhalturin@zoologie.uni-kiel.de
Abstract:
Urochordates possess several well described allorecognitions systems, the molecular nature of those is not yet understood. A prerequisite for any self-/nonself discimination system is the presence of a group of highly variable molecules, which should vary between individuals. Using suppression subtractive hybridisation (SSH) we surveyed Ciona intestinalis for individually variable genes. Our search so far identified two genes, ciS7 and ciMETA2, which both display an unexpected high degree of intra- and interindividual variability, code for secreted proteins, and contain multiple domains suitable for protein-protein interactions. The possible role of these molecules in allorecognition is discussed.
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