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Related Experiment Videos

Capillary electrochromatographic chiral separations with potential for pharmaceutical analysis.

Debby Mangelings1, Mohamed Maftouh, Yvan Vander Heyden

  • 1Department of Pharmaceutical and Biomedical Analysis, Pharmaceutical Institute, Vrije Universiteit Brussel-VUB, Laarbeeklaan 103, B-1090 Brussels, Belgium.

Journal of Separation Science
|June 9, 2005
PubMed
Summary

Capillary electrochromatography (CEC) shows promise for chiral separations in pharmaceutical analysis. Chiral stationary phases, particularly those with macrocyclic antibiotics and polysaccharides, are favored for direct chiral separations.

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Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Pharmaceutical Analysis

Background:

  • Chiral separation is critical in pharmaceutical analysis to distinguish enantiomers.
  • Capillary electrochromatography (CEC) offers a unique approach combining electroosmotic flow and chromatographic separation.
  • Reviewing recent advancements in CEC for chiral separations is essential for pharmaceutical applications.

Purpose of the Study:

  • To review the application of capillary electrochromatography (CEC) as a chiral separation technique in pharmaceutical analysis.
  • To focus on publications from the past 10 years with practical pharmaceutical applications.
  • To analyze method development, validation, separation strategies, and routine analysis potential.

Main Methods:

  • Literature review of publications over the last decade.

Related Experiment Videos

  • Focus on studies with direct and indirect chiral separation methods in CEC.
  • Analysis of different chiral stationary phases (CSPs) and chiral mobile phases (CMPs).

    • Main Results:

    • Direct chiral separations using CSPs were more prevalent than CMPs.
    • Macrocyclic antibiotics and polysaccharide selectors were the most common CSPs.
    • Monolithic stationary phases showed applications but were less common than packed capillaries.

    Conclusions:

    • CEC is a viable technique for chiral separations in pharmaceutical analysis, with readily producible stationary phases.
    • Further development is required to overcome current disadvantages and establish CEC as a mature separation technique.