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Capillary electrochromatography using polyelectrolyte multilayer coatings.

Mary W Kamande1, Kristin A Fletcher, Mark Lowry

  • 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.

Journal of Separation Science
|June 9, 2005
PubMed
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Polyelectrolyte multilayer (PEM) coatings offer simple and effective solutions for open-tubular capillary electrochromatography (OT-CEC) separations. These coatings improve analyte separation and stability by reducing adsorption and enhancing electroosmotic flow.

Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Materials Science

Background:

  • Capillary electrochromatography (CEC) is a powerful separation technique.
  • Traditional CEC methods face challenges with analyte adsorption and flow stability.
  • Polyelectrolyte multilayers (PEM) offer a versatile surface modification strategy.

Purpose of the Study:

  • To review recent advancements in PEM coatings for analytical separations.
  • To highlight the advantages of PEM coatings in open-tubular capillary electrochromatography (OT-CEC).
  • To discuss the application of PEM coatings in various separation platforms.

Main Methods:

  • Review of literature on polyelectrolyte multilayer coatings.
  • Focus on applications in open-tubular capillary electrochromatography (OT-CEC).

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  • Discussion of surface modification principles and separation mechanisms.

    • Main Results:

    • PEM coatings provide a simple preparation method for capillary columns.
    • PEM coatings effectively reduce the adsorption of basic analytes.
    • Improved separation efficiency and enhanced stability of electroosmotic flow are achieved.
    • PEM coatings are applicable to fused-silica capillaries and microchip devices.

    Conclusions:

    • PEM coatings represent a significant advancement in OT-CEC.
    • The versatility of PEM coatings allows for the separation of diverse analytes, from small molecules to biomolecules.
    • PEM coatings offer a promising approach for developing robust and efficient analytical separation systems.