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Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic
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[Mastitis caused by Yersinia pseudotuberculosis in a cow]
O C Sampimon1, J Sol, M G J Koene
1Gezondheidsdienst voor Dieren, Postbus 9, 7400 AA Deventer. O.Sampimon@gdvdieren.nl
Tijdschrift Voor Diergeneeskunde
|June 9, 2005
Summary
A cow diagnosed with subclinical mastitis was infected by Yersinia pseudotuberculosis, a bacterium also capable of infecting humans. This marks the first detection of this pathogen in Dutch mastitis cases, highlighting a potential zoonotic risk.
Area of Science:
- Veterinary Medicine
- Microbiology
- Zoonotic Diseases
Background:
- Subclinical mastitis is a common udder infection in dairy cows, often characterized by elevated somatic cell counts.
- Yersinia pseudotuberculosis is a Gram-negative bacterium known to cause various infections in animals and humans.
Observation:
- A cow in her fifth lactation presented with subclinical mastitis and a high somatic cell count.
- Yersinia pseudotuberculosis was identified as the causative agent, representing a novel finding in The Netherlands.
Findings:
- Despite antibiotic treatment during the dry period, the Yersinia pseudotuberculosis infection persisted in the affected quarter.
- The cow experienced reduced milk production and persistently high somatic cell counts in subsequent lactation.
- No evidence of pathogen spread to other quarters or herd mates was observed over a one-year monitoring period.
Implications:
- This case highlights Yersinia pseudotuberculosis as a potential pathogen in bovine mastitis, with implications for animal and public health due to its zoonotic potential.
- Persistent infection despite treatment suggests challenges in eradicating Yersinia pseudotuberculosis from dairy herds.
- Further research is warranted to understand transmission dynamics and develop effective control strategies for Yersinia pseudotuberculosis mastitis.
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